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1 bottles | $29.77 | $29.77 | ADD TO CART | |
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Undifferentiated sarcoma Definition A malignant mesenchymal tumour, usually high-grade, lacking specific differentiation. Histopathology the tumour cells have a storiform, fascicular or diffuse growth and are typically associated with infiltrative borders. The cells are spindle to stellate and show variable degrees of pleomorphism and brisk mitotic activity. This should be a diagnosis of exclusion after eliminating the also rare, but more often reported, carcinosarcoma, adenosarcoma with sarcomatous overgrowth, specific sarcomas, gastrointestinal stromal tumour, melanoma, or even a mixed tumour of the vagina if the cytological features of the tumour are low-grade 1493. Rhabdomyosarcoma Definition A malignant tumour exhibiting skeletal (striated) muscle differentiation. Clinical features Approximately 90% of embryonal rhabdomyosarcomas occur in infants and children < 5 years of age (mean 1. Symptoms related Angiomyofibroblastoma Definition this is a benign tumour composed of myofibroblasts and blood vessels. Mesenchymal tumours 219 Clinical features this is a tumour of adult women occurring in the vulvovaginal region (see also vulva chapter, p. Aggressive angiomyxomas can rarely show areas with angiomyofibroblastoma-like features 663. Histogenesis Angiomyofibroblastoma is believed to originate from mesenchymal cells that are capable of myofibroblastic differentiation 585,762. Histopathology Characteristically, this is a hypocellular, myxoid neoplasm with interspersed, and often evenly spaced, small to mediumsized vessels, which may be thick-walled and hyalinised. The myxoid matrix also contains wispy collagen and small collections of smooth muscle, which are more commonly located near the vasculature. The stromal cells are typically bland spindle-shaped cells with ovoid nuclei and delicate uni- to bipolar cytoplasmic processes. Prognosis and predictive factors these tumours have a propensity to recur, particularly if incompletely excised. Histopathology these are well-circumscribed but unencapsulated lesions growing beneath unremarkable squamous epithelium. There are typically areas of alternating cellularity with cells containing bland ovoid, spindle or stellate-shaped nuclei, often with a somewhat wavy appearance, embedded in a finely collagenous stroma, sometimes with thicker collagen bundles. Multiple patterns, including lace-like, sieve-like and fascicular are frequently present, resulting in a heterogeneous appearance. This is a non-specific immunophenotype which is identical to many other vulvovaginal mesenchymal lesions. Histogenesis these are thought to arise from the subepithelial hormone receptor-positive mesenchymal region which extends from the endocervix to the vagina. Prognosis and predictive factors these are benign lesions which are treated by local excision. Although they may occasionally recur locally, there have been no reports of metastasis or malignant transformation.
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C the smooth endoplasmic reticulum is involved in the transport of materials throughout the cell, in lipid synthesis, and in the detoxification of drugs and poisons. Both mitochondria and nuclei are surrounded by double membranes, eliminating choices (B) and (C). Ribosomes must not be surrounded by membranes because they are found not only in eukaryotes, but also in prokaryotes, which lack any membrane-bound organelles, eliminating choice (D). C the main differences between prokaryotes and eukaryotes include: prokaryotes do not have a nucleus, while eukaryotes do, eliminating choice (B); prokaryotes have ribosomal subunits of 30S and 50S, while eukaryotes have ribosomal subunits of 40S and 60S, eliminating choice (A); and prokaryotes do not have membrane-bound organelles, whereas eukaryotes do, eliminating choice (D). The presence of a membrane on the outer surface of the cell could not distinguish a prokaryotic cell from a eukaryotic one because both gram-negative bacteria and animal cells share this feature. C Tubulin is the primary protein in microtubules, which are responsible for the structure and movement of cilia and flagella, eliminating choices (A) and (B). Microfilaments are not composed of tubulin, but rather actin, making choice (C) the correct answer. C Viruses can exist in either the lytic or lysogenic cycle; they may even switch between them throughout their lifetime. In the end, the host cell bursts (lyses) and releases new virions, each capable of infecting other cells. Either spontaneously or as a result of environmental circumstances, the provirus can reemerge and enter a lytic cycle. Thus, choices (A) and (B) are incorrect because they reverse which part of the cycle the virus is in. Choice (D) describes features of bacteriophages, which are viruses that infect bacteria - not the human nervous system. C Bacterial cells reproduce by binary fission, an asexual process in which the progeny is identical to the parent. Conjugation can be described as a sexual mating in bacteria; it is the transfer of genetic material between two bacteria that are temporarily joined. Transduction occurs when fragments of the bacterial chromosome accidentally become packaged into viral progeny produced during a viral infection and can subsequently be introduced into another bacterium by the viral vector. A A bacterial cell that does not rapidly cause a phenotypic change in the rest of the colony is likely not F+, meaning that this cell is not able to form a sex pilus for conjugation. The expression of new phenotypic characteristics indicate that this bacterium may have acquired some quantity of genetic information, which can be acquired by either transformation, choice (B), or transduction (which occurs via bacteriophage infection), choices (C) and (D). Primarily, prions cause a shift toward -pleated sheet confirmations, which leads to decreased solubility and degradability of proteins, ultimately leading to disease. In this Chapter the Cell Cycle and Mitosis the Cell Cycle Control of the Cell Cycle Mitosis 2. Prototherians (monotremes), which include the duckbilled platypus and echidna (spiny anteater), encase their developing embryos within hard-shelled amniotic eggs and lay them to be hatched, like reptiles. It might seem a bit strange that something as essential as reproduction could be so different between mammalian species, but the truth is that there is a wide variety of reproductive mechanisms in nature.