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Portal vein stenosis is identified on Doppler ultrasonography by the presence of normal proximal flow, a high-velocity jet at the anastomosis, and distal turbulence. Air in the portal vein has occasionally been detected on Doppler ultrasonography as highly echogenic, nonshadowing particles moving within the portal vein. Although air was reported in one case in association with a gangrenous colon,85 it may be a transient finding without other serious complication in the first 2 weeks after transplantation. Celiac angiogram shows a severe stenosis of the hepatic artery with numerous collaterals in the porta hepatis. Confusion of these collaterals with the main hepatic artery may lead to erroneous interpretation of the ultrasound study and result in the false-positive interpretation that the hepatic artery is patent. A, Flush aortogram shows the stump of an occluded donor iliac artery graft from the infrarenal aorta to the liver transplant (arrow). A mild irregularity consistent with residual thrombus is seen in the hepatic artery. The patient could not be treated with heparin because of heparin allergy; reocclusion occurred, necessitating retransplantation. The portal vein is entered via a transhepatic puncture; after entry to the portal system is achieved, pressures are measured across the stenosis and balloon angioplasty is performed. Success was obtained in two patients, both of whom were asymptomatic at 1 year follow-up. We routinely perform portal vein angioplasty in patients, usually children who develop portal vein stenosis after transplant. Olcott et al88 described their experience with balloon angioplasty in four patients with portal vein occlusion. Three of the four treated patients died of multiple problems unrelated to the angioplasty. The researchers also described the placement of a metal stent in a patient with portal vein occlusion. This patient died of a brain abscess 1 month later, and the stent was patent at autopsy. However, thrombus developed above the stent and failed to lyse with thrombolytic therapy. In a large series of more than 2200 transplantations, Zajko et al59 observed 10 cases of stenosis and two cases of thrombosis. The "piggyback anastomosis" (with preservation of the recipient vena cava and cavocaval anastomosis) may result in venous obstruction. Delayed caval stenosis may be due to fibrosis, a chronic thrombus, or neointimal hyperplasia.
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Division of the main vascular and biliary structures can be delayed if necessary and completed on the back table (to speed up the dissection or review recipient anatomy). Recipients Receiving Right Lobe Grafts (Extended) In general, partial grafts corresponding to left lateral segments have better results that right lobes. However, the reported results are still similar to those obtained from using marginal whole grafts with the additional benefit of decreasing the time on the waiting list. A North American survey56 reported good results obtained from using 152 partial grafts (left lateral segment and right lobe [extended]) (54% ex situ and 46% in situ). The rate of vascular complications was low (5% equally distributed between hepatic artery and portal vein thrombosis), and incidence of biliary complications was 11% (82% were cut surface or anastomotic leaks and 18% were anastomotic biliary strictures). Yersiz et al57 reported similar results; however, other series have reported higher rates of biliary complications rising up to 34%. These rates of complications were similar to those described in left lateral segments from living donation and to whole grafts from pediatric donors. A liver from a donor less than 40 years old, with a weight greater than 20 kg and with intensive care unit stay less than 5 days should be split preferentially by the pediatric transplant center. There is, however, some concern regarding the outcomes for the split right lobe graft in small-volume adult transplant centers. Variations in outcomes of right lobe split grafts have been noted between centers and whether grafts are imported. Several factors may contribute to these outcomes, including the reported 18% hepatic artery thrombosis rate, 30% early graft dysfunction rate, and 23% retransplantation rate. Donor and recipient selection criteria and surgical decision making and proficiency appear to be key. In Italy there was no difference in morbidity between the two different grafts for hepatic artery thrombosis (7%), biliary complications (26%), primary nonfunction (4. The majority of cases have been performed in a small number of centers, which tend to have larger volume and to have active adult and pediatric transplant programs. The allocation of a good-quality donor liver to a child for split left lateral segment transplant with the subsequent offer of the right lobe to an adult recipient has been suggested as a way of increasing splitting. Mandatory splitting of suitable livers has been introduced in some countries, such as the United Kingdom, and this does appear to help maintain numbers. Debate continues as to which surgeons and centers should be performing liver splitting and how to monitor outcomes and identify technical shortcomings. Balancing the needs of pediatric liver transplantation with those of adult recipients who are too sick to receive partial grafts continues to be a source of tension in allocation systems. Liver division to safely obtain grafts for two adult recipients remains a technical challenge, although results are improving. Further challenges include the optimization of cadaveric donors, recipient selection, and sharing of livers.